Fibromyalgia may be caused by injury, emotional distress, or viruses that change the way the brain perceives pain, but the exact cause is uncertain. People with rheumatoid arthritis, lupus, and spinal arthritis may be more likely to develop a disease. The hallmarks of fibromyalgia include chronic musculoskeletal pain, severe fatigue, and sleep and mood disturbances.
Patients may also experience psychological distress, including depression and anxiety. They also use antidepressants to deal with these issues. People with fibromyalgia can have irregular levels of Substance P in their ACR spinal fluid. This chemical helps to send and intensify signals of pain to and from the brain.
The role of Substance P studies and other neurotransmitters is being investigated and scientists are trying to find out why people with fibromyalgia have increased sensitivity to pain and whether there is a gene or gene that makes a person more susceptible to it.
Pain medicines, antidepressants, muscle relaxants, and sleep medicines are commonly used to treat people with fibromyalgia. For the treatment of fibromyalgia in particular, Lyrica (pregabalin) became the first FDA-approved medication in June 2007; Cymbalta (duloxetine hydrochloride) became the second one a year later in June 2008; and Savella (milnacipran HCI) became the third one in January 2009. In some people with Lyrica fibromyalgia, Cymbalta and Savella decrease pain and improve function.
People suffering from fibromyalgia have been shown to experience pain in a different way from others; the mechanism by which these drugs produce their effects is mysterious. Information indicates that these drugs influence the release of neurotransmitters in the brain.
Neurotransmitters are chemicals which transmit signals from one neuron to another. Treatment with Lyrica, Cymbalta, and Savella can reduce the rates of pain felt by some people with fibromyalgia.
FDA approves generic Duloxetine for fibromyalgia
Duloxetine is a major anxiety condition in adults. Duloxetine is also used in adults and children who are at least 7 years of age to treat general anxiety disorder. In adults, Duloxetine can be used to relieve severe muscle or joint pain (such as low back pain and osteoarthritis pain) or fibromyalgia (chronic pain disorder).
“We are pleased to receive this FDA consent, which adds to our growing line of central nervous system acting agents. Hai Wang, President of Solco Healthcare, said in a press release that we continue to strengthen our presence in the US generic market by providing high quality medicines at reasonable prices. Scientists say Duloxetine works by increasing the levels of serotonin and noradrenaline neurotransmitters in the nervous system.
The effects of Duloxetine in fibromyalgia patients were contrasted with those of acetyl-L-carnitine depression therapy. They also reduced stress and suffering, and increased the physical quality of life of patients. But only duloxetine improved the psychological quality of life of patients. In decreasing the pain of patients with fibromyalgia and improving both their other symptoms and their quality of life, Duloxetine did a considerably better job than placebo. It was also safe and well tolerated by patients.
Duloxetine may improve your mood, sleep , appetite, and energy levels, and reduce your nervousness. This can also reduce discomfort due to other medical problems. Duloxetine is known to be a serotonin-norepinephrine reuptake inhibitor (SNRI). This medicine restores the balance of certain natural substances (serotonin and norepinephrine) in the brain.
How to use?
If instructed by your doctor, take this medication by mouth, usually 1 or 2 times a day with or without milk. If you have diarrhea, it can help you to take this medication with milk. Swallow the capsule whole. Do not crush or chew the capsule or mix with food or liquid. This can lead to the release of whole drugs at once, increasing the risk of side effects. The dosage is dependent on your age , medical condition and reaction to medication.
Your doctor may direct you to start this medicine at a low dose and slowly increase your dose to reduce your risk of side effects. Ignore the guidance of the doctor closely. Take this medicine every day to get the most out of it. To help you remember, take it at the same time each day. Even if you feel well, it is important to continue taking this medication as prescribed.
Do not stop taking this medicine without consulting your doctor. Some conditions may worsen when this drug is suddenly stopped. Symptoms such as anxiety, dizziness, mood swings, fever , nausea , vomiting, sleep changes, and clear, electrical shock-like sensations may also occur. To avoid side effects, the dosage can need to be reduced gradually. State any new or deteriorating symptoms immediately.
Side effects include loss of hunger, increased sweating, vomiting, dry mouth, constipation, exhaustion, or somnolence. If any of these effects persist or worsen, tell your doctor immediately. Especially when you start or increase your dosage of this medication, you can feel weak or lightheaded. To raising the chance of fainting, fainting, or collapsing, stand up slowly when rising from a sitting or lying position.
Your doctor has found that the value of this drug to you is higher than the risk of side effects, which is why your doctor has administered this medication to you. Keep that in mind. A lot of people who use this medicine have no serious side effects. This medicine may increase your blood pressure.
Check your blood pressure regularly and tell your doctor if your blood pressure is high. If any of these serious side effects occur, tell your doctor immediately: confusion, decreased interest in sex, easy bruising / bleeding, changes in sexual ability, muscle cramps / weakness, shaking (tremor), signs of liver problems (such as stomach / abdominal pain, persistent nausea , vomiting, difficulty urinating, yellowing eyes / skin, dark urine).
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Study Reference: Duloxetine for the treatment of fibromyalgia via NCBI