Hyperalgesia Amplified Pain in Fibromyalgia and ME/CFS

Hyperalgesia is an increased fibromyalgia (FMS) pain response and chronic tiredness (ME / CFS) response. It is so important in fibromyalgia that it defines the condition essentially. Just make your body feel more painful than it should when you have hyperalgesia.

This is often called “volume rotation” of pain. It’s a real, physiological phenomenon and not because of hypochondria, for example. It is not the result of a person “doing a lot of things out of nothing” as some people might think.

Facts about Hyperalgesia

  • “Medication Overuse Pain” is also recognized for hyperalgesia
  • Hyperalgesia due to opioid drugs is generally seen in the prescription of high opioid doses in medical conditions such as chronic headache or pain.
  • Recent evidence indicates that use of chronic opioids only causes the glial cell’s IV pain recipient to activate, which leads to an inflammatory condition in pain recipients, resulting in a hyperalgesia intensification of the pain impulse.
  • After chronic opioid treatment, opioids have proven to be responsible for chronic hyperalgesia.
  • Acute hyperalgesia is seen in patients who have surgery under general anesthesia after postoperative pain management with opioids.
  • Fibromyalgia leads to chronic neuropathic pain and is also known as hyperalgesia.

Hyperalgesia and Central Sensitivity Syndromes

Bowel syndromes (BMS, ME / CFS, irritable bowel syndrome, leg ruining syndrome and several other diseases) are a common underlying feature of a group of diseases called center-level sensory syndromes. Some inflammatory conditions and damage to certain kinds of nerves are also associated with it.

In addition, hyperalgesia is an immune systemic cell reaction that your body releases as a result of infection, called proinflammatory cytokines. In some ME / CFS cases theoretical pro-inflammatory cytokines are present. Many treatments for FMS and ME / CFS, at least in part, are targeted at reducing hyperalgesia (it is not yet known whether this is because of ongoing infections or because a chronically activated immune system).

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The pain type is different from allodynia typical in FMS and is present in some cases in ME / CFS. Anti-depressing (for example, Cymbalta, Savella and amitriptyline) and anti-seize medicines (including Lyrica and gabapentin).

Allodynia is a pain reaction to something that is usually not painful, like a light touch. Allodynia is often referred to as’ skin pain,’ which is usually expressed as extreme susceptibility to pressure or skin movement.

Hyperalgesia in Fibromyalgia: Neuropathic Pain

  • When you want to explain the neuropathic pain, both hyperalgesia and allodynia can be performed.
  • The caused neuropathic pain is fibromyalgia.
  • Hyperalgesia differs from allodynia entirely. Hyperalgesia is an increased feeling of pain following painful stimuli where allodynia increases the sense of pain caused by unanimous stimuli such as simple skin palpation.
  • Opioid-induced hyperalgesia is different from fibromyalgia-induced hyperalgesia.
  • The hypersensitivity of pain to noxious as well the non-noxious stimuli caused by fibromyalgia is significantly improved.

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Hyperalgesia also may be a reaction to the immune systems, which your body releases in reaction to the infection, called the pro-inflammatory cytokines. In some cases the presence of ME / CFS pro-inflammatory cytokines is theorized. (The ongoing infection or the chronically activated immune system are not clear yet.)

Scientific study performed by Burgmer M et al.

Patient suffering from the hyperreaction of the central nervous system occasionally causes hyperalgesia for chronic diseases such as fibromyalgia. One study involving 34 patients consisted of seventeen fibromyalgia patients and seventeen standard control groups in two groups.

Burgmer M et al. conducted a scientific study and published it in 2012. Each patient in the two groups had a right volar forearm experimental incision. Hyperalgesia primary and secondary was assessed and recorded. Changes in hyperalgesia were correlated with brain activation (imagery with magnetic function).

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Test results indicate that central-level (brain) pain transmission in patients with fibromyalgia has been altered. In normal patients, similar MRI changes have not been observed. These findings have been linked to changes in pain inhibition cerebral-midbrain-spine mechanisms.

In patients with fibromyalgia, hyperalgesia is a common symptom. Fibromyalgia symptoms often cause diagnosis, tolerance or dependence on the opioid. In large fibromyalgia-patients who are not taking chronic opioids, hyperalgesia is a dominant symptom.

Using a new therapy

When using a new therapy, your medical history is always important. Ask many questions and research what you can do to help your fibromyalgia pain. All are different, and if certain therapies aren’t working immediately, it’s all right. Your doctor may diagnose you with a certain type of fibromyalgia if you have a diagnosis of fibromyalgia. The diagnosis you receive should be paid attention.

“Hyperalgesia” diagnosis means excessive pain, or it may have amplified your pain. Those who have fibromyalgia of this kind may experience pain that appears to be amplified. For instance, a person is bumping into an corner. You feel like you’ve been sticky and tears to your eyes, but you probably haven’t reacted this way in the past.

Treatment of Hyperalgesia

  • There is rotating opioid treatment for patients with symptoms of hyperalgesia.
  • Opioid changes help hyperalgesia prevention.

The rotation of opioids may not be affected by hyperalgesia. In these cases, opioids are prescribed for following medications.

  • NSAIDs
  • Ketamine local application
  • Neurontin or Lyrica
  • Muscle Relaxants: Baclofen, Flexeril or Skemaxin

Prevention of Hyperalgesia:

The rotation of different opioids can prevent hyperalgesia within about six months. Auditioning antagonists of NMDA receptors, such as dextromethorphan, methadone or opioid ketamine, also helps to prevent hyperalgesia.

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Reference: fight fibromyalgia.

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